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Blood Test for Cancer : Types and Their Importance

21 Jan, 2025

This article is medically reviewed by Dr. Jyoti Ranjan Swain, Consultant - Surgical Oncology, HCG Panda Cancer Hospital, Cuttack.

Table of Contents

Overview

Blood tests play a pivotal role in the diagnosis, monitoring, and management of different types of cancer. They help identify abnormalities, detect cancer markers, and provide insights into overall health.

Technological advancements have led to the development of some crucial blood tests for early cancer detection, such as the Galleri test, tumor marker blood test, and circulating tumor cells test.

The Internet is flooded with information on a blood test for cancer, a blood test to detect cancer, or a blood scan for cancer. Consuming information from so many sources can be overwhelming.

Through this article, we are trying to provide all the necessary information about blood tests in one place.

Can Cancer Be Detected Through Blood Tests?

"Can blood tests detect cancer?"

This is a burning question that we start this detailed article with.

The answer is yes.

Blood tests are capable of detecting some forms of cancer, but not all. Usually, blood tests look for identifiable tumor or cancer markers, proteins, or tumor cells roaming in the bloodstream.

The importance of blood tests cannot be overstated in the detection phase, as they help a great deal in determining whether more advanced investigations like CT scans or biopsies are needed. They form a crucial part of cancer management.

What Cancers Are Detected by Blood Tests?

If a patient is suspected to have cancer, blood tests may be recommended to look for tumor markers (which may be proteins, genes, or other substances), cancer cells, or DNA from tumor cells. These observations from blood tests can help doctors determine if additional tests are required to arrive at a conclusive diagnosis.

The following are the different cancers that can be detected by blood tests:

The importance of these tests cannot be overstated, as they help in the early detection of cancer, increase the efficiency of treatment, and enhance the chances of survival. They highlight the potential of a blood test for cancer in its nascent stages.

Types of Blood Tests for Cancer Diagnosis

1. Complete Blood Count (CBC) Test

A fundamental diagnostic tool is the complete blood count test. It measures red blood cells, white blood cells, hemoglobin, and platelets. To illustrate, abnormal counts, like high or low WBCs, can be a sign that someone has cancer, e.g., leukemias and lymphomas.

2. Blood Protein Test

Blood protein tests are used to check for abnormal proteins such as M-proteins linked to multiple myeloma. Even though they do not indicate cancer in particular, these tests are combined with other diagnostic procedures to confirm their validity.

3. Tumor Marker Blood Tests

The tumor marker blood tests identify proteins or antigens manufactured by cancerous cells. These markers aid in the diagnosis of patients and also in monitoring the effectiveness of treatment.

It is important to note that elevated levels of tumor markers are associated with various non-cancerous conditions as well. Therefore, it is important to not just rely on cancer marker blood tests and undergo additional tests for an accurate diagnosis.

4. Circulating Tumor Cells Test

The circulating tumor cells test is crucial for identifying cancerous cells that are present in the bloodstream as well as determining metastasis. It is important in monitoring patients with breast, prostate, and colorectal cancers.

Does Early Cancer Show in Blood Tests?

There is no one blood test to find cancer in the early stages. There are many blood tests that are recommended to look for the presence of tumor growth in the body. In some cases, these tests can help in early detection of different types of cancer, even before they become apparent. These tests may also help in detecting cancers that show no symptoms in the early stages, i.e., silent cancers.

1. The Galleri Test

The Galleri test is an innovative discovery that can identify more than 50 cancer types. It works by examining the DNA released by tumors in the blood, offering an opportunity to identify cancers before symptoms appear.

2. Proteomics-Based Plasma Test

The examination of protein patterns in blood using proteomics plasma tests helps in the recognition of anomalies linked to cancer. Even though it is not yet fully developed, this is a very promising technology that could completely change how we detect cancer at its earliest stages.

Can Blood Tests Detect Tumors?

The presence of tumors can be indirectly detected through blood tests that identify abnormal proteins, cancer markers, or circulating tumor cells. While they cannot definitively confirm a tumor’s presence, they often guide further diagnostic imaging like CT or MRI scans. Tests like tumor marker blood tests and the Galleri test are very important, serving as the first indication of cancer.

How Do Cancer Blood Tests Work?

Blood tests for cancer operate by analyzing components in the blood to identify irregularities associated with cancer. Such abnormalities may comprise increased levels of tumor markers, proteins, or the presence of circulating tumor cells (CTCs).

Key Points:

  • Cancer Detection via Blood Tests:Blood tests can detect abnormalities like tumor markers, proteins, or circulating tumor cells (CTCs).
  • Tumor Marker Tests: The tests pick out proteins or antigens that are specific for cancer, like PSA, which is used in the detection of prostate cancer; CA-125—ovarian cancer and AFP—liver cancer.
  • Complete Blood Count (CBC):Abnormal counts of white or red blood cells in a CBC may indicate blood cancers like leukemia.
  • Advanced DNA Detection:The Galleri test can detect tumor-shed DNA (cfDNA) fragments. It is useful for more than 50 types of cancer, most of which can be identified at their initial stage.
  • Circulating Tumor Cell (CTC) Tests:These tests look for cancer cells in the bloodstream to monitor disease progression and metastasis.
  • Treatment Monitoring: It is possible to monitor the effectiveness of oncology treatment by doing blood tests that show changes in tumor markers or residual cancer cells.

Blood tests are important because they enable one to diagnose, monitor progress, and customize the treatment of any disease.

Cancer Diagnosis at HCG

At HCG, which is a leading hospital for cancer treatment in India, we have revolutionized cancer diagnostics and treatment. We offer comprehensive screening and diagnostic programs for cancer detection and diagnosis through state-of-the-art methodologies such as the Galleri test, tumor marker blood test, and circulating tumor cells test, along with complete blood count tests as well as other specific blood tests to find cancer. These tests aim at detecting cancers in their early stages when they can be effectively treated with excellent clinical outcomes.

Conclusion

In the detection and treatment of cancer, blood tests play a very important role. These tests enable us to recognize specific markers and keep track of circulating tumor cells for immediate, efficient treatment as well as follow-up care. Even though certain cancers cannot be detected by these tests alone, advancements like the Galleri test and tumor marker blood test increase the chances of early detection and timely treatment.

Frequently Asked Questions

A complete blood count test can reveal certain types of blood cancer, such as leukemia and lymphoma. In case the numbers of any of the three types of cells (white blood cells, red blood cells, platelets) are not normal, additional tests may be recommended for a conclusive diagnosis.

For the majority of blood examinations recommended for cancer detection, there is no need for any special preparation. Nevertheless, a few of them may demand that you fast for some hours or stay away from particular medications.

During cancer blood work, the lab technician will draw blood from a vein in your arm. This is a quick procedure that lasts for not more than two minutes. It is not very painful except for the needle prick.

You may feel slight pain or notice bruising where the blood was drawn. Results are usually ready in a few days, and your doctor will review them and discuss the next steps during your follow-up.

Most of the time, blood tests are harmless. The usual risks are little bruises, small bleeding, or brief dizziness. There is a low probability of getting any serious complications.

Normal blood test results don’t always rule out cancer, as some types may not cause abnormalities in the blood. Additional tests like imaging or biopsy may be needed for confirmation.

Ovarian cancer can indeed be identified through blood tests such as the CA-125 tumor marker test. However, these tests are not definitive and are often used in conjunction with imaging and other diagnostic methods.

References

Author Bio

Dr. Jyoti Ranjan Swain
Consultant - Surgical Oncology
MBBS, MS, FICS, FACS, MCh (Surgical Oncology)

Dr. Jyoti Ranjan Swain is an experienced surgical oncologist with vast experience in performing various cancer surgeries. He is available for consultations at HCG Panda Cancer Hospital, a top-ranking cancer hospital in Cuttack. His treatment approach is to provide the best quality of care for his patients by providing the latest surgical techniques and evidence-based medical practices. He also believes in a multidisciplinary approach to cancer treatment and strives to provide comprehensive care to his patients.

To book an appointment with Dr. Jyoti Ranjan Swain, please click here.

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